О влиянии вариации rs679620 MMP3 гена на риск возникновения разрыва передней крестообразной связки в европеоидной популяции Уральского региона России. Выявлено отклонение от РХВ (P = 0,014), связанное с недостатком гетерозиготных носителей.
Anterior cruciate ligament (ACL) rupture of knee joint is severe multifactorial injury. The aim of this study was to determine whether a variant rs679620 within MMP3 gene associates with the risk of ACL rupture in Europoids of Ural region of Russia. Fifty-five patients with diagnosed ACL ruptures and 298 healthy controls were genotyped for the MMP3 rs679620 variation. Both groups were similar on a sex, age, growth, weight and BMI. Genotypic frequencies in controls meet Hardy- Weinberg equilibrium (HWE). The deviation from HWE was detected in group with ACL rupture (P = 0,014). It was related to insufficiency of heterozygotes. Goodness of fit test didn't reveal reliable difference between genotypic frequencies of 2 groups (P = 0,098). This study suggests that there is a weak (if any) relationship between the MMP3 rs679620 variation and a ACL rupture in the Russian Europoid population.
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