The study of genetic traits in athletes specializing in Sambo wrestling may track possible routes of genetic selection and find some molecular-genetic markers, which provide success in this particular sport. Genetic survey of Sambo wrestlers all Altaic nationality has been performed. Altogether 48 individuals (only males), 17- 32 years old have been investigated. Genotypes of the subjects were determined for the polymorphic genetic system of the АСЕ gene. The study shows the presence of genetic selection among Sambo wrestlers of high qualification. The analysis of frequency distribution of the genotypes of АСЕ gene demonstrates some nonrandom statistical differences between athletes with different sports level. Thus, in the sample of highly qualified athletes the frequencies of DD genotype of АСЕ gene (27.3% vs 10.0%, X2 = 10.3, P = .006) are higher. Deletion (D) allele of the АСЕ gene is associated with the increased speed-power capacities of athletes. Consequently, selective advantage is given to those Altaic Sambo wrestlers who have deletion allele of the ACE gene (ACE*D), genotypes DD and ID.